- Scrawled notes
- Scrawled notes/Transcript
- Scribbled notes
- Scribbled notes/Transcript
- Script of Hazeel
- Scroll
- Scruffy note
- Scruffy note/Transcript
- Scrumpled piece of paper
- Scrumpled piece of paper/Transcript
- Scythe
- Sea Slug
- Sea turtle
- Seaman Lorris
- Seaman Lorris/Dialogue
- Seaman Thresnor
- Seaman Thresnor/Dialogue
- Seaslug
- Seasoned Sardine
- Seaweed
- Seer
- Seer/Dialogue
- Seers' Village
- Serevel
- Serevel/Dialogue
- Server
- Seth
- Seth/Dialogue
- Sewer valve
- Shadow Warrior
- Shadow spider
- Shallow water
- Shaman robe
- Shamans Tome
- Shamans Tome/Transcript
- Shantay
- Shantay/Dialogue
- Shantay Desert Pass
- Shantay Pass
- Shantay Pass Guard
- Shantay Pass Guard/Dialogue
- Shantay Pass Shop
- Shapeshifter
- Shar
- Shark
- Shark certificate
- Shears
- Sheep
- Sheep Herder
- Sheep Shearer
- Shield
- Shield (scenery)
- Shield of Arrav
- Shilo Village
- Shilo Village (location)
- Shilo Village (quest)
- Shilo Village mine
- Shilop
- Shilop/Dialogue
- Shiny Key
- Ship
- Ship Ticket
- Ship yard
- Shipyard foreman
- Shipyard foreman/Dialogue
- Shipyard worker
- Shipyard worker/Dialogue
- Shock bolt
- Shop
- Shop Assistant
- Shop Assistant/Dialogue
- Shopkeeper
- Shopkeeper/Dialogue
- Short Sword
- Shortbow
- Shrimp
- Sidney Smith
- Sidney Smith/Dialogue
- Siegfried Erkle
- Siegfried Erkle/Dialogue
- Sigbert the Adventurer
- Sigbert the Adventurer/Dialogue
- Sign
- Sign (gnome)
- Signpost
- Silk
- Silk Stall
- Silk merchant
- Silk merchant/Dialogue
- Silk trader
- Silk trader/Dialogue
- Silver
- Silver Stall
- Silver bar
- Silver bar certificate
- Silver certificate
- Silver merchant
- Silver merchant/Dialogue
- Silver rock
- Silverlight
- Silverlight key 1
- Silverlight key 2
- Silverlight key 3
- Sinclair Crest
- Sinclair Mansion
- Sinister Chest
- Sinister key
- Sinister stranger
- Sinister stranger/Dialogue
- Sink
- Sir Amik Varze
- Sir Amik Varze/Dialogue
- Sir Gawain
- Sir Gawain/Dialogue
- Sir Lancelot
- Sir Lancelot/Dialogue
- Sir Mordred
- Sir Percival
- Sir Percival/Dialogue
- Sir Prysin
- Sir Prysin/Dialogue
- Sir Radimus Erkle
- Sir Radimus Erkle/Dialogue
- Sir Vyvin
- Sir Vyvin/Dialogue
- Sito Foil
- Skavid
- Skavid/Dialogue
- Skavid caves
- Skavid map
- Skeleton
- Skeleton mage
- Skeleton mage/Dialogue
- Skill mastery
- Skills
- Skirt
- Skull
- Skull (PKing)
- Slang
- Slave
- Slave/Dialogue
- Slave (disambiguation)
- Slave robes
- Slaves Robe Bottom
- Slaves Robe Top
- Slayer
- Sleeping Bag
- Slice of Cake
- Smashed chair
- Smashed table
- Smithing
- Smithing training
- Snake Weed
- Snakes Weed Solution
- Snape grass
- Soda ash
- Soft Clay
- Soil
- Soldier
- Sorcerors' Tower
- Soul-Rune
- Souless
- Souless (slave)
- Souless (slave)/Dialogue
- Sound effects
- Spade
- Spawning
- Spear
- Spearwall
- Special curry
- Specimen brush
- Specimen jar
- Specimen tray
- Speedy Keith
- Spell scroll
- Spell scroll/Transcript
- Spellbook
- Spice
- Spice crunchies
- Spice merchant
- Spice merchant/Dialogue
- Spices Stall
- Spider
- Spider (disambiguation)
- Spiked pit
- Spinach roll
- Spinning wheel
- Spirit Tree
- Spirit Tree/Dialogue
- Spirit of Scorpius
- Spirit of Scorpius/Dialogue
- Sprite
- Squire
- Squire/Dialogue
- Staff
- Staff of Air
- Staff of Armadyl
- Staff of Iban
- Staff of Iban (broken)
- Staff of Saradomin
- Staff of earth
- Staff of fire
- Staff of guthix
- Staff of water
- Staff of zamorak
- Stairs
- Stake
- Stalactite
- Stalagmite
- Stamped letter of recommendation
- Standard
- Stanford The Gardener
- Stanford The Gardener/Dialogue
- Stankers
- Stankers/Dialogue
- Stat restoration Potion
- Stats
- Statue
- Statue of glarial
- Staves
- Steel
- Steel 2-handed Sword
- Steel Arrows
- Steel Axe
- Steel Chain Mail Body
- Steel Kite Shield
- Steel Long Sword
- Steel Mace
- Steel Pickaxe
- Steel Plate Mail Body
- Steel Plate Mail Legs
- Steel Plate Mail top
- Steel Plated skirt
- Steel Scimitar
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